Use this software on your own risk :-) Additional resourcesĠ.1.1, 11-02-17 - Now supports Python 3.xĠ.1.2, 11-02-17 - Now supports Python on Windows machinesĠ.1.3, 11-02-17 - Now supports Python on Windows machines, minor changesĠ.1.4, 12-02-17 - Guided main menu implemented that presented when CanvasSync is invoked without parametersĠ.1.5, 13-02-17 - Files locked for the user will no longer be downloaded, fixed some Python 3 related errorsĠ.1.6, 08-03-17 - Minor bug fixes, add package version. Resources that the user has access to on the server on the users behalf.ĬanvasSync is still in its early version and is not guaranteed to be stable. Modified/rogue versions of the software could however use the authentication token to remove or modify The official version of CanvasSync will only pull resources from the server and never remove or modify resources on the CanvasSync stores the authentication key encrypted and locally and the key is never shared with 3rd parties. Please note that by using CanvasSync the user allows the software to authenticate with the Canvas server on the usersīehalf. Passwords and/or auth tokens areĬannot and will not be shared with third parties. Specify the password whenever CanvasSync is launched to synchronize at a later time. The authentication token is stored in an local file encrypted using a private password. The process of generating a token is illustrated below: Please note thatīy supplying an authentication token to the CanvasSync software, you allow CanvasSync to communicate with the Canvas server on A token is a substitution to the familiar username-password based authentication and allowsģrd party applications such as CanvasSync to authenticate with the Canvas server API and pull resources. Near the bottom under the ‘Approved integrations’ section, a new authentication Going to the ‘Account’ section followed by ‘Settings’. Order to authenticate with the server an authentication token must be generated on the Canvas web server. p to specify settings password (potentially dangerous) SetupĬanvasSync uses the Canvas LMS API ( ) to pull resources on the Canvas server. s or –setup will prompt the user to reinitialize settings i or –info will display the currently saved settings Prompt the user to enter new settings if no previous settings could be found. When launched without commandline arguments, CanvasSync will start synchronizing with previously specified settings or If you choose not to work with PIP, CanvasSync has the following dependencies that must be installed: DependenciesĪfter installation CanvasSync is launched by executing the following command in the console: Lastly, you may use the supplied setup.py file to create your own source package or built package for your system. zip for Windows) and run the following command on the distribution file: Download and install CanvasSync along with itsĪlternatively, download the source distribution from the on GitHub The easiest way to install and run CanvasSync is by using PIP. If CanvasSync should attempt to find external files described in the assignment description Installation ![]() ![]() What type of items to be synchronized (files, HTML pages, external links) ![]() The user may specify various settings including: Lastly, all files that do not fall into the above categories are downloaded and stored in the ‘Various Files’ folder. ![]() Bothįiles stored on Canvas as well as external files will be detected. May download Canvas assignments along with all linked files that can be found in the description of the assignment. Web pages as well as Canvas ‘Pages’ (HTML pages) representing assignments etc. SyncFolder/Course/Module/SubFolder/file.txt. It traverses the folder hierarchy in Canvas from the top course level down to individualįiles and creates a similar folder structure on the local computer:įirst, CanvasSync creates a folder hierarchy on the local computer reflecting the ‘Modules’ section on the Canvas server.įiles are stored in folders such as. To a mirrored folder on their local computer. DescriptionĬanvasSync helps students automatically synchronize modules, assignments & files located on their institutions Canvas web server Synchronise modules, assignments and files located on a Canvas by Instructure web server to your local computer.
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The DATEDIF function is useful in formulas where you need to calculate an age. By default, Januis serial number 1, and Januis serial number 39448 because it is 39,447 days after January 1, 1900. ![]() DATEDIF ('' '' 'md') Here the function calculates the difference between the two dates in days but ignoring years and months. Dates are stored as sequential serial numbers so they can be used in calculations. With this number format code you can represent any number as a time difference. Here the function calculates the difference between the two dates in whole months but ignoring years, showing that it is 1 month since Philippes 38th birthday. An easy example would be to use :MM:SS (am/pm makes no sense for time differences) which tells the number formatter that you don't want to calcuate times modulo 24 hours. In your case you want to show negative time (or time differences) so you want to represent negative numbers like -0.1 as -02:24:00 which requires you to adapt the number format code. DATEDIF ('' '' 'md') Here the function calculates the difference between the two dates in days but ignoring years and months. The number format code that corresponds to 12:00:00 AM is HH:MM::SS AM/PM which says that the time should be calculated modulo 24 hours and AM/PM applied automatically. Here the function calculates the difference between the two dates in whole months but ignoring years, showing that it is 1 month since Philippe's 38th birthday. > How can I achieve this He probably meant B1-A1. I'm using this spreadsheet for office > productivity. In column C I would > like to calculate the difference of column B and column A in > minutes or hours. I enter data > into these columns in the format hh:mm. Use the MONTH function to obtain the month value for each date, and then calculate the difference between the values. Column A contains the > start time and column B contains the end time. ![]() Excel treats months as values (1 through 12), which makes it easy to subtract an earlier date from another date as long as both dates fall in the same year. The second important thing to understand is that the number format code tells you how your value is interpreted. You can use the following operators in Calc: arithmetic, comparative, text, and reference. Calculate the number of months between two dates in the same year. Now if you add the default time format you'll get something like 12:00:00 AM (for an en-US locale, for other locates the representation looks different). The value 1 represents 24 hours when formatted as time or one day past the zero date (can be changed in the options). It doesn't use helper columns - I have hard-coded the shift patterns instead. I ended up with this, working off the sheet in post #32. As with JeteMc it seemed like there should be a neater solution but it turned out the code got a lot longer to deal with the weekend bit. The first movie was surprisingly devoid of blood and gore.Leatherface isn't the only villain, he's one of multiple fucked-up characters. The best things about Texas Chainsaw Masscare: Netflix VPN and proxy discussion Network/Streaming Subreddits r/WatchItWithMeĭevoted to watching and discussing one movie a week together /r/NetflixByProxy Make sure to be signed in! Netflix CalendarĬonsolidated view of what's on Netflix Official Netflix Pagesĭitch your cable/satellite TV and stream for cheap or free /r/CordcuttingĬutting the cord, but keeping it legal. Shows absolutely everything in the genre/sub-genre you select. UK (United Kingdom) new streaming titles site Netflixcodes Submit "best of" or "worst of" instant titles there Netflix Instant Watcherįind new or about to expire streaming titles (make sure you are logged into Netflix to add to your queue from Instant Watcher) Flixfilm To view the spoiler, simply hover your cursor over the text.įailure to mark spoilers, or intentionally posting spoilers will get you banned. (This makes it easier to skim the page and power users can search by tag to find relevant threads.) Comment SpoilersĪdd the scope of the spoiler in the brackets. If your thread applies to every Netflix country, use ALL. Flair your thread with your country if the issue/question is specific to programming in your country. MAKE A SELF POSTĪnd not a screen grab to suggest a movie or link to the movie on the Netflix site. Please contact us first if you have a question about your app/page. Post that in /r/NetflixByProxy No blogspam reviews or spamming about your app or webpage. No, we won't even bother to discuss this with you. Please don't ask if you can buy or share an account. Netflix uses the term “original” to delineate between movies and series that are exclusive to its platform, and those that are aggregated from other studios after first being made available elsewhere. No threads about Netflix not making some netflix originals. "Hey Netflix, you need to do this" thread is heard by nobody that can change it. This subreddit is not owned or moderated by Netflix or any of their employees. Rules and Guidelines Limit threads suggesting changes to Netflix. Threads that fall under content/functionality are subject to removal at moderator discretion. Any issues with Netflix (content and/or functionality) should be addressed directly with Netflix customer service. R/Netflix is NOT affiliated with Netflix corp in any way, shape or form. Members can play, pause and resume watching, all without commercials or commitments. Members can watch as much as they want, anytime, anywhere, on any Internet-connected screen. Netflix is the world's leading internet entertainment service with over 148 million paid memberships in over 190 countries enjoying TV series, documentaries and feature films across a wide variety of genres and languages. This can of course be alleviated with vehicles, but then you pay the price of being a massive target for enemy forces. This is especially true when you’re first starting out or when you end up on a poor team since you’ll be dying more often. Most of what you’ll see as you traverse the landscapes on your way to your next destination are large empty fields lined with the same bushes and trenches that you saw in the last map, and while this is probably more realistic than loading up each map with all sorts of interesting locations, it also can make long stretches of gameplay feel a bit dry as you will spend a rather large chunk of your playtime crossing big swaths of the map. These pockets of highly engrossing areas don’t encompass the majority of most maps though. The environments are generally well-crafted and highly detailed with dilapidated fences, partially-incinerated houses, and other ravages of war abound. Respect for the game’s general concepts and themes aside, on a technical level it’s a bit more of a mixed bag. "While its unforgiving nature might be an acquired taste for many, and it likely won’t really click with you until you’re several hours in, this particular road to hell is likely worth traveling for those looking for a truly hardcore World War 2 simulator." When a rigid strategy comes into conflict with unexpected complications, your team’s mettle will be tested, and you will either sink or swim together. But everyone also needs to be able to think on their feet and pick up players’ slack at a moment’s notice, and this is where a lot of the spice of Hell Let Loose comes from. All of which have their own unlockables that slowly fall into place as you use them. Soldiers within each 6-player unit are tasked with carrying out their specific duties whether that be medical, engineering, assault, support, or other focuses. ![]() One can voice chat with their designated unit, with whoever is near their current location, or of course commanders can functionally talk to the entire army by talking directly with leaders of each unit. ![]() As previously mentioned though, communication is the main key here. Both of which are basically centered around the concept of a huge map where up to 100 players compete for control of the map’s handful of zones scattered throughout the area while a timer ticks away. ![]() Once on the ground, you’ll want to immediately begin and sustain constant communication with as many of your squad mates as possible, as the most organized and efficient team of 50 is often the winner of the game’s 2 main modes Offensive and Warfare. Hell Let Loose doesn’t waste much time before thrusting you into its mix of first person shooting and real-time warfare strategy. While its unforgiving nature might be an acquired taste for many, and it likely won’t really click with you until you’re several hours in, this particular road to hell is likely worth traveling for those looking for a truly hardcore World War 2 simulator. It proudly wears its intentions as well as its flaws on its sleeve and makes no apologies for either. If that is the case, then Black Matter’s Hell Let Loose might just be the ticket for you. It might be that your gaming palette just demands something a bit more methodical and grounded now. If the twitchy, arcade-y run ‘n guns that populate the vast majority of the first-person shooter genre aren’t doing it for you these days, you may not be having a problem with the genre per se’. ![]() Manufacturer of humane bird-control products: stainless-steel needle strips, Fliteline wire deterrent & 3 types of bird netting visual, chemical & audible systems free technical & planning services with direct order. I think it would have worked best & been easier to apply on a brand new hull. I put it on my boat last season & Im happy with it. Manufacturer of bird & pest control products: SPIKES Needle Strips, sticky gels, nets, ultrasonic & visual devices for landmark status, museums, industrial, commercial & residential properties. RejeX is a tough, air-cured, impermeable high-gloss, ultra-slick polymer sealant and finish that provides unmatched protection against surface deterioration easily outlasting and outperforming other wax-type products. Basically if the rejex is still good the wax won’t stick so you’re wasting your time and money. Manufacturer of humane, effective bird control products: professional-grade bird spikes, bird netting, electric bird track, visual, chemical & audible systems stainless steel & polycarbonate spikes Bird Net 2000, Bird Jolt Flat Track & Bird Shock Track extensive base of authorized installers who are available for consultation & installation. Goose repellent for turf, and TP-40 for fogging warehouses, barns, etc. Manufacturer and distributor of ‘ReJeX-iT’ bird repellents that humanely manage and control bird populations. Traditional Building - April 2021 Bird Control RejeX shines better and lasts longer than any wax Recently named a Top 10 Boat. ![]() ![]() ^ (2007) "Walking tour of Little Italy May 9"."Condos will build on neighborhood's past". (nd) Magic Number:Third stage in downtown Omaha development charging ahead Archived at the Wayback Machine. (1939) Nebraska: A Guide to the Cornhusker State. (1936) Omaha: A Guide to the City and Environs. (nd) A Comprehensive Program for Historic Preservation in Omaha. ^ Press Release from the Office of the Mayor, City of Omaha (June 2, 2008) City and Neighbors Partner to Preserve and Enhance South Omaha Corridors.^ "Reconnaissance Survey of Portions of South Central Omaha, Nebraska: Historic Buildings Survey" (PDF).(1997) The Gate City: A history of Omaha. In 2007 Caniglia's was razed, and was replaced with townhomes. Other landmarks include the Santa Lucia Festival Committee Hall at 725 Pierce Street Marino's Italian Grocery at 1716 South 13th Street Sons Of Italy Hall located at 1238 South 10th Street, and Orsi's Bakery at 621 Pacific Street. The Cornish Residence is one of Omaha's best examples of Second Empire style architecture, and Santa Lucia Hall, which was originally built in 1891 as Fire Station 9. Francis Cabrini Church, designed by Thomas Rogers Kimball and built in 1908 at 1335 South 10th Street. ![]() Little Italy has several landmarks, including St. Many other remnants of Little Italy endure, making this area distinct within the city. Several new housing developments are happening throughout the area, as well. In addition to the historic Italian families in the area, today there are Latinos, Eastern Europeans and others throughout the community. An annual festival called "La Festa" is held to unite the city's Italian community and celebrate heritage. Today the Festival of Santa Lucia, which was started by Grazia Caniglia, is still celebrated throughout Little Italy, as it has been since the arrival of the first immigrants. According to one expert, Little Italy native Tony Biase was the "leading Mafioso in Omaha" through the 1970s. Later, from 1946 to 1951, Calamia controlled the local outlet of a national race wire service, distributed racing results received from the mob-controlled Harmony News Service in Kansas City. In 1930, Omaha city boss Tom Dennison placed Frank Calamia, a Sicilian living in the neighborhood, in charge of liquor syndicate operations in Omaha's south side. The Immigration Act of 1924 was largely responsible for ending large-scale immigration of Italians to Omaha.ĭuring the Prohibition era, much of the Omaha's bootleg liquor was produced in Little Italy. Originally Little Italy had a small commercial area on South 6th Street extending west along Pierce Street, including a grocery store, clothing and shoe stores, and the Bank of Sicily, established by the Salerno brothers in 1908. South 10th Street was also particularly important to the Italian community. Additional waves of Sicilians arrived between 19 and following World War I. In 1905, Sicilian immigrants settled along South 6th Street in the hills south of downtown. Joseph then secured boarding and jobs for the immigrants, particularly in downtown Omaha's Union Pacific shops. When Sebastiano took a job as an agent for a steamship company in 1904, he encouraged friends from Sicily to emigrate. Two brothers, Joseph and Sebastiano Salerno, are credited with creating Little Italy, located further north near the Union Pacific yards in downtown. It was formed by immigrants from southern Italy and migrants from eastern American cities. Omaha's first Italian enclave developed during the 1890s near the intersection of South 24th Street and Poppleton Street. The plan calls for 10th Street to be improved with a streetcar line, treelines, parks, fountains and sculpture. In June 2008, the City of Omaha has announced plans to revitalize the area because of its proximity to Nebraska's top two tourist attractions, the Old Market District and the Henry Doorly Zoo. It is located immediately south of the Burlington Train Station and the Omaha Rail and Commerce Historic District. The community is bounded by Pacific Street on the north, Center Street on the south, South 10th Street on the west and the Missouri River on the east. ![]() It was the source of many laborers for the Union Pacific railroad, much of Omaha's bootlegging during Prohibition and the Santa Lucia Procession, which started in 1924 and continues annually. Little Italy is a neighborhood in Omaha, Nebraska which served as the historic home to Omahans of Italian ancestry. ![]() While on the last mission of her life, Kate forms an unlikely bond with Ani.Ĭan Kate exact vengeance on her killer before dying from the poison? It’s a race against the clock and there’s no time for mercy. Kate’s mission leads her to the biggest yakuza family in Tokyo, and a teenage girl Ani who has the information she needs. Kate decides to dedicate her last moments to hunt down her killer. Kate (Mary Elizabeth Winstead), guided by her wily handler, Varrick (Woody Harrelson), has been a. She wakes up in the hospital and learns that the poison has spread too fast, and she has less than15 hours to live. The thriller Kate is an undistinguished action film that makes a hero of a hit woman. Kate is an experienced assassin who realizes she’s poisoned after messing up a hit job. The trendy teen and stoic assassin is always a recipe for success. While the story is intense, there’s always time in between for comedic moments between characters. Kate seems to balance the grittiness of a revenge thriller with some humor. Kate will stop at nothing to kill her killers before it’s too late. This action-packed thriller spans across the city of Tokyo in neon cars and high-speed chases, martial arts fights and machine guns. Japanese singer-songwriter and actor MIYAVI also has a role in Kate, and it will be Martineau’s debut in feature film. You may know Kunimura as Boss Tanaka from another brutal female assassin revenge thriller, Kill Bill. Its refreshing to see Netflix deliver a solid 'run and. Winstead plays the stoic assassin, joined onscreen by Woody Harrelson, Miku Martineau and Jun Kunimura. 'Kate' seems to have pulled Harrelsons 'Zombieland' gag of looking for a specific treat throughout the movie and not finding it anywhere. A bit more like his character in The Hunger Games.įinally, Miku Patricia Martineau managed to make a huge and profound impact on me as the young, but fierce, Ani.Mary Elizabeth Winstead stars in the new movie Kateon Netflix soon! This revenge action-thriller comes from the minds who made Atomic Blonde and John Wick. Kate 2021 Maturity rating: MA 15+ 1h 46m Action Slipped a fatal poison on her final job, a ruthless assassin working in Tokyo has less than 24 hours to find out who ordered the hit and exact revenge. T he first episode of the Bridgerton prequel series, Queen Charlotte: A Bridgerton Story, opens with a disclaimer from none other than the notorious Lady Whistledown. This is a classic Woody role, but not as comedy-heavy as the Zombieland-movies nor as dark as True Detective. In Kate (Netflix), Mary Elizabeth Winstead has 24 hours to find out who poisoned her. ![]() YOU MIGHT LIKEĪlong with Mary Elizabeth Winstead, you’ll see Woody Harrelson in a key role as Kate’s mentor and handler. Profile: Kate Arnold of Netflix 285 this, as they had the 30-day free trial month, which bought them the extra time they needed). Still, to me, 10 Cloverfield Lane was a defining role of hers. If you’ve been cooling off with Netflix recently, you may have come across the recently-released film Kate, starring Mary Elizabeth Winstead as the titular assassin with 24 hours to live, and an unquenchable thirst for revengeand Boom Boom Lemon drink. ![]() Hell, she was John McClane’s daughter in both Die Hard 4.0 (2007) and A Good Day to Die Hard (2013). After she was left orphaned as a child, Varrick. I’m not looking away anymore, Kate dramatically says in the film’s third act as a way to describe how the past 24 hours have changed her. ![]() I mean, sure, I know she was in Scott Pilgrim vs The World (2010) and in Death Proof (2007). Kate is an assassin and expert sniper who eliminates targets chosen by her trusted mentor and handler, Varrick. (music by) Cinematography by Lyle Vincent. To me, Mary Elizabeth Winstead first made a huge impact with her starring role in 10 Cloverfield Lane (2016). Kate (I) (2021) Full Cast & Crew See agents for this cast & crew on IMDbPro Directed by Writing Credits Cast (in credits order) complete, awaiting verification Produced by Music by Nathan Barr. She then went on to play one of the leads in Lovecraft Country which were truly a kick-ass series. In fact, Birds of Prey also introduced Jurnee Smollett in a kick-ass action role as “Black Canary”. In other words, action scenes where she’s a skilled fighter are not new to her. If you’ve been cooling off with Netflix recently, you may have come across the recently-released film Kate, starring Mary Elizabeth Winstead as the titular assassin with 24 hours to live, and an unquenchable thirst for revengeand Boom Boom Lemon drink. She was also in the Harley Quinn movie Birds of Prey: And the Fantabulous Emancipations of One Harley Quinn (2020) as “The Huntress”. I’ve always liked Mary Elizabeth Winstead and the portrayal of the title character in Kate is no exception. ![]() ![]() In general, to add/subtract two rational expressions: If the denominators of two rational expressions are already the same, then we can add/subtract their numerators directly. To add/subtract rational expressions, first rewrite the fractions with a common denominator. Thus, the simplest form is (y + 2) / (2y + 3), where y ≠ 0, -3/2.Īdding and Subtracting Rational Expressions Note that we shouldn't use the denominator of the simplest form while calculating the restrictions. To find the restrictions, set the original denominator ≠ 0 and solve. To simplify the given expression, we just factorize the numerator and denominator and cancel the common terms. Note that the restrictions are any values that make the denominator equal to 0, including any canceled terms while simplifying.Įxample: Simplify the rational expression (3y 2 + 6y) / (6y 2 + 9y).
The game launches July 15 on PC via Steam and Nintendo Switch. What Comes After Publisher Releasing New Game on Steam and Switchįrom Spanish publisher Flynn’s Arcade and retro video game developer Radin Games, Lambs on the Road is a survival horror about a father searching for his daughter in a post-apocalyptic world. There is strategic, turn-based tactical combat, varied story campaigns and mystical elements. The game’s narrative allows players to create hero characters and follow them over their whole careers, “from their pitchfork days to their powerful primes,” making choices to affect the story. “Thanks to Picogram’s imaginative world, we believe Garden Story will provide both a relaxing escape and a lasting positive message for players when the game launches later this year.”Ĭharacter Driven RPG Wildermyth Launches on Steamįrom husband and wife duo Nate and Anne Austin at Texas-based studio Worldwalker Games, Wildermyth is a character-driven RPG with a procedural-style storytelling system. “ Garden Story’s emphasis on fostering community perfectly aligns with everything Rose City Games stands for,” said Will Lewis, co-founder and director, Rose City Games, in a statement. In the pixel-art filled world, players can harvest tools for combat, solve puzzles and conquer dragons. The game, which releases on Nintendo Switch and PC via Steam this summer, follows a young grape who takes on a guardian role and protects the four realms of The Grove. Portland-based publisher Rose City Games and developer Picogram debuted the trailer for action-RPG Garden Story during Summer Game Fest’s Day of the Devs. ![]() 12 on Nintendo Switch, Xbox One, Xbox Series S/X, Xbox Game Pass, PC via Steam and Itch.io and Amazon Luna.Īction-RPG Garden Story Releasing This Summer He is anothet fucking Hitler scum cunt and should stop hiding behind a desk and fight his war full on like a man and not a fucking pussy.'Angry Birds' Maker Rovio Agrees to $775M Sale to Sega If only enough people could rebel against their government and take over, but this is a guy who has made sure people don't get the right to vote him out. ![]() I feel for both sides, obviously the Ukraine folks, but the Russian soldiers who are forced by their country to fight this war. I am from Britain and I would fight to defend Ukraine, our government are a bunch of over paid pussy cockroaches and they know putin could wipe majority of the uk out if he wanted to launch a nuke.Īnd how no one saw the possibility of this tyrant doing this, we waste time setting Iraq up with false news and media when the never had the weapons Putin is no different than Hitler seeking to wipe for no reason. Good timing tho how troops are withdrawn just shortly after this shit starts. The "U.N" claim its here to protect people, america claims it fights for peoples rights or should we say, if there is something that interests them. Putin doesn't give a fuck, he is sat on the motherland of nuclear power and as we all know human rights dont qualify when it comes to warlords selling weapons, ammunition, ammo, body armour, ration kits, tanks and the list goes on. Ohh lets give him a slap here or there and sanction this or that and force professionals out of there career. Isn't it sad that we have spent the last decade fighting for a false war (again) with the Americans over "potential" nuclear weapons of mass destruction.Īnd here we have fucking Putin, no one darea challenge him. If you want to support the cause, or just pick up a ton of DRM-free games for cheap, you can check out the bundle at the source below. Right now, Itch.io has raised $1.7 million out of a $2 million goal, with 9 days left to go. The bundle costs $10, and contains games like CrossCode, SkateBIRD, SUPERHOT, Celeste, TowerFall Ascension, and hundreds of other indie games. The Bundle for Ukraine collects nearly 1,000 works over 700 different creators, with all money raised by purchases of the bundle to go directly to Ukrainian charities-specifically International Medical Corps, who is providing medical aid to those affected, and Voices of Children, a charity that helps Ukrainian children have safe shelters to be, and help them handle PTSD. The latest gaming-related support comes from Itch.io, who is no stranger to charity bundles, having previously raised money for racial injustice and Palestine. Whether it's John Romero creating a DOOM II level to raise money for the Ukrainian Red Cross, the team behind This War of Mine donating all proceeds of sales to Ukraine, or the swaths of companies removing their products from sale in Russia, a lot has been happening within the industry. ![]() Game developers, studios, and publishers are coming together to support Ukraine. ![]() This statement is in relation to the current shortage of Ga68 PET radionuclide. This will address the shortage or lack of availability of somatostatin analogue PET agents that we are currently experiencing in many parts of the U.S.” Ga68 PET Shortages explained “Once approved, 64Cu-Dotatate will be available to patients in medical centers with PET capability across the country. The radionuclide is not new, it’s been in use for some time, mainly in Denmark.Ħ4Cu is a PET isotope that can be produced at a central location in quantities to meet the commercial needs of hospitals and imaging centers without the supply limitations of nuclear generator-based PET isotopes,” said Ebrahim Delpassand, MD, CEO of RadioMedix. This partnership builds on the initial development work conducted by RadioMedix and will benefit from Curium’s regulatory, manufacturing, distribution, and commercial expertise. RadioMedix is currently engaged in Phase III clinical trials of the agent and expects to file a New Drug Application with the Food and Drug Administration in 2019. announce an exclusive agreement to develop and commercialize 64Cu-Dotatate, an investigational positron emission tomography (PET) diagnostic agent for patients with Neuroendocrine Tumors (NETs). Read more by clicking here.Ĭurium and RadioMedix Inc. Read more here.Įdit : RadioMedix and Curium Announce FDA Fast Track Designation For 64Cu-Dotatate. US FDA announced approval of Ga68 DOTATOC. The objective of this trial is to provide patients with confirmed or suspicion of NET access to Copper Cu 64 Dotatate for the detection, localization, and monitoring of SSTR expressing NETs.Įdit. Expanded Access Program via clinical trial now recruiting – see below. Majority read revealed Detectnet had over 98% accuracy, 100% sensitivity, and over 96% specificity to confirm or exclude presence of disease. 64Cu-dotatate now named Detectnet™ is approved for use by US FDA. The imaging time window of 64Cu-DOTATATE positron emission tomography/computed tomography (PET/CT) for patients with neuroendocrine neoplasms can be expanded from one hour to three hours post-injection, according to new research published in the January 2021 issue of The Journal of Nuclear Medicine. |